Methotrexate may cause very serious, life-threatening side effects. You should only take methotrexate to treat cancer or certain other conditions that are very severe and that cannot be treated with other medications. Warning Very bad side effects like bone marrow problems, liver problems, lung problems, infections, and skin reactions (Stevens-Johnson syndrome/toxic epidermal necrolysis) can happen with methotrexate injection (subcutaneous). Methotrexate is a powerful medication that can be used for many serious conditions. MTX is an antineoplastic (anticancer) drug that is used in protocols to treat all kinds of cancers such as leukemias, lymphomas, and breast cancers. I have suffered with scalp psoriasis for 5 yrs. I tried all the RX creams. Now I have been on methotrexate for 3 months. The past 6 weeks I have been experiencing major dizziness throughout each day of the week. Having googled side effects there is some suggestion that it can cause dizziness. Does anyone les get this, a feeling of disorientation at best up to full on dizziness? This has been happening to me for 6 months but as time goes on it is becoming more and more prevalent. honeyadams, I haven't actually got any experience of taking Methotrexate. I haven't read of other MTX takers complaining of a vertigo side effect in the past but dizziness is listed as a less common side effect. I take methotrexate every week and feel sick to my stomach and can barely eat for at least 3 days; on weeks when I have to take Actemra Injections I feel sick longer. Unfortunately methotrexate is the first drug in over a year that is controlling the pain, inflammation, and joint damage from RA so I am stuck dealing with it. Methotrexate is a powerful medication that can be used for many serious conditions. MTX is an antineoplastic (anticancer) drug that is used in protocols to treat all kinds of cancers such as leukemias, lymphomas, and breast cancers. Summary. Dizziness is found among people who take Methotrexate, especially for people who are female, 60+ old , have been taking the drug for 1 - 6 months, also take medication Humira, and have Psoriatic arthropathy. Neurologic complaints– dizziness, headache, difficulty concentrating, are infrequent but can occur. Often, these complaints occur soon after the weekly dose. With repeated doses, these problems often get better on their own.